When configuring a Linux host running either Red Hat Linux 6, Red Hat Linux 7, CentOS 6 or CentOS7 with two network interface cards (NIC) that each have an IP address in a different network or subnet, you could end up in a situation where one of the IP addresses isn’t reachable outside it’s own network. Both IP’s will be responding to a ping from another host in the same network as those IP addresses but only one is responding to ping from another network. On most other distributions, like Debian, this issue, which is caused by asymmetric routing, doesn’t seem to exist.
Besides using NAT for accessing the internet with multiple machines using a single IP address, there are many other uses of NAT. One of them is to forward all traffic that is sent to a certain TCP port to another host. In practice, this technique can be used to test a service on a new host without adjusting anything on the client. The users or the clients do not need to be pointed to a new machine in order to test it. When the test would be unsuccessful, removing the NAT-rule is all it takes to switch back.